Veratric acid

Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant^[1] and anti-inflammatory activities^[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling^[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation^[3]. IC50 & Target: COX-2^[3] In Vitro: Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation and HDAC3 expression in RAW264.7 cells^[1].
Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis^[3].
Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation^[3]. In Vivo: Veratric acid (40 mg/kg, p.o., b.w.) significantly promotes ventricular function, reduces lipid peroxidation and increases antioxidants in l-NAME-induced hypertensive rats^[2].