Fasnall


CAS No. : 929978-58-5

929978-58-5
Price and Availability of CAS No. : 929978-58-5
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10mg $195 In-stock
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Cat. No. : HY-121250
M.Wt: 338.47
Formula: C19H22N4S
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 929978-58-5 :

Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. Fasnall induces apoptosis in HER2+ breast cancer cell lines. Fasnall shows potent anti-tumor activities[1]. IC50 & Target:IC50: 3.71 μM (human purified FASN activity)[1] In Vitro:Fasnall potently blocks both acetate and glucose incorporation into total lipids, with IC50 values of 147 and 213 nM, respectively, in HepG2 cells[1].
Fasnall (50 μM; 24-120 h) inhibits proliferation in breast cancer cell lines[1].
Fasnall (25-100 μM; 24 h) induces apoptosis in HER2+ breast cancer cell lines[1]. In Vivo:Fasnall (15 mg/kg, intraperitoneally, twice weekly; 3 weeks) shows potent anti-tumor activity in MMTV-Neu model of HER2+ breast cancer[1].

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