DG051
CAS No. : 929915-58-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $510 | In-stock |
| 50mg | $810 | In-stock |
| 100mg | $1300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-10825 |
| M.Wt: | 426.33 |
| Formula: | C21H25Cl2NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 325 mg/mL |
DG051 is a potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC50=47 nM. IC50 & Target: IC50: 47 nM (LTA4H)[1] In Vitro: DG051 is a potent inhibitor of LTA4H aminopeptidase activity against L-alanine p-nitroanilide (IC50=72 nM). DG051 inhibits human whole blood (HWB) with IC50 of 37 nM. As applied within the context of LTA4H inhibitor design, the chemistry team is able to design a potent DG051(Kd=26 nM) with high aqueous solubility (>30 mg/mL) and high oral bioavailability (>80% across species) that is currently undergoing clinical evaluation for the treatment of myocardial infarction and stroke[1] DG-051 is a first-in-class small molecule inhibitor of leukotriene A4 hydrolase (LTA4H), currently in Phase II clinical development for the prevention of heart attack[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- DG051
- Cat. No.:
- HY-10825
- Quantity:
Your information is safe with us.