GSK461364 analogue 1
CAS No. : 929095-23-8
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| Cat. No. : | HY-111090 |
| M.Wt: | 511.04 |
| Formula: | C26H27ClN4O3S |
| Purity: | >98 % |
| Solubility: |
GSK461364 analogue 1 is a thiophene-based PLK1 inhibitor with a PLK1 IC50 of 2 nM and a PLK3 IC50 of 630 nM. GSK461364 analogue 1 also acts as an inhibitor of Nek2 kinase (IC50: 21 nM). GSK461364 analogue 1 has a solubility of ≥190 μM in pH 7.4 PBS and a human plasma protein binding rate of 91.5%. GSK461364 analogue 1 can be used in studies related to colon cancer, lung cancer, breast cancer and ovarian cancer[1].
In Vitro:GSK461364 analogue 1 (2 h) inhibits the proliferation of HCT116 colorectal cancer cells, with an IC50 of 11 nM[1].
GSK461364 analogue 1 (h) potently inhibits the proliferation of various human tumor cell lines (colon, lung, breast, ovary), with an IC50 value ranging from 3 to 11 nM[1].
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- GSK461364 analogue 1
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