Pracinostat (dihydrochloride)
CAS No. : 929016-98-8
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| Cat. No. : | HY-105246 |
| M.Wt: | 431.40 |
| Formula: | C20H32Cl2N4O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pracinostat dihydrochloride is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat dihydrochloride also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM[1][4]. IC50 & Target:IC50: 40 nM (HDAC10), 43 nM (HDAC3), 47 nM (HDAC5), 49 nM (HDAC1), 56 nM (HDAC4), 70 nM (HDAC9), 93 nM (HDAC11), 96 nM (HDAC2), 137 nM (HDAC7), 140 nM (HDAC8), 1008 nM (HDAC6)[1]
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