PF 03716556
CAS No. : 928774-43-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $69 | In-stock |
| 10mg | $108 | In-stock |
| 25mg | $216 | In-stock |
| 50mg | $408 | In-stock |
| 100mg | $768 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13100 |
| M.Wt: | 394.47 |
| Formula: | C22H26N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 23 mg/mL (ultrasonic;warming) |
PF 03716556 is a potent, selective, competitive and reversible acid pump (H+,K+-ATPase) antagonist with pIC50s of 6.026, 6.038 and 6.009 for porcine, canine, and human recombinant gastric H+,K+-ATPase, respectively. PF 03716556 is inactive against other receptors, ion channels, and enzymes. PF 03716556 has the potential for gastroesophageal reflux disease research[1]. IC50 & Target:pIC50: 6.026 (Porcine gastric H+,K+-ATPase), 6.038 (Canine gastric H+,K+-ATPase) and 6.009 (Recombinant gastric H+,K+-ATPase)[1] In Vitro: In porcine ion-tight membrane vesicles, PF 03716556 inhibits H+,K+-ATPase activity in a concentration-dependent manner, with a pIC50 value of 7.095 at pH 7.4[1]. In Vivo: PF 03716556 (1-10 mg/kg; intraduodenal administration; once; male Sprague-Dawley rats) treatment inhibits gastric acid secretion in a dose-dependent manner in rats[1].
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