KC7F2
CAS No. : 927822-86-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $66 | In-stock |
| 25mg | $139 | In-stock |
| 50mg | $231 | In-stock |
| 100mg | $341 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18777 |
| M.Wt: | 570.38 |
| Formula: | C16H16Cl4N2O4S4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 32 mg/mL |
KC7F2 is a potent hypoxia inducible factor-1 (HIF-1) pathway inhibitor with an IC50 of 20 μM in LN229-HRE-AP cells, and with potential as a cancer therapy agent[1].
IC50 & Target: IC50: 20 μM (HIF-1, LN229-HRE-AP cells)[1]
In Vitro: KC7F2 (15–25 μM; 0-72 hours) exhibits a clear dose-response cytotoxicity with an IC50 value of approximately 15–25 μM depending on the cell lines, and this effect is more severe under hypoxic conditions[1].
KC7F2 (0-80 μM; 6 hours) specifically reduces the protein levels of HIF-1α in a dose-dependent manner under hypoxic conditions; strongly decrease in HIF-1α levels at concentrations above 20 μM[1].
KC7F2 does not affect the rate of HIF-1α protein degradation[1].
KC7F2 inhibits HIF-1α protein synthesis but not its mRNA transcription[1].
KC7F2 represses the phosphorylation of eukaryotic initiation factor 4E binding protein 1 (4EBP1)[1].
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