Cefprozil
CAS No. : 92665-29-7
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| Cat. No. : | HY-B0458A |
| M.Wt: | 389.43 |
| Formula: | C18H19N3O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Cefprozil is a second-generation cephalosporin type antibiotic. Cefprozil exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections[1][2].
In Vitro:Cefprozil inhibits S. pyogenes, S. pneumoniae, S. agalactiae, S. aureus (methicillin-susceptible), H. influenzae, M. catarrhalis, E. coli with MIC90s of 0.04, 0.23, 0.3, 1.4, 6.7, 4.5, 12.2 mg/L, respectively[2].
In Vivo:Cefprozil (two doses, injection) exhibits antibacterial activity against E. coli, H. influenzae, K. pneumoniae, P. mirabilis, S. aureus (β-lactamase-negative), S. aureus (β-lactamase-positive), S. pneumoniae, and S. pyogenes in mouse models, with ED50s of 2.0, 3.1, 2.8, 1.5, 0.04, 18, 1.0 and 0.08 mg/kg, respectively[2].
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