SRT 1460
CAS No. : 925432-73-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $176 | In-stock |
| 25mg | $253 | In-stock |
| 50mg | $385 | In-stock |
| 100mg | $583 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124037 |
| M.Wt: | 507.60 |
| Formula: | C26H29N5O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues[1].
IC50 & Target: EC1.5: 2.9 μM[1]
In Vitro: SRT 1460 (2-6 μM; 72 hours) inhibits cell viability in a dose-dependent manner, with all pancreatic cancer cells being more sensitive than the control HPDE cell. The IC50s of those cells are: Patu8988t, 1.62±0.13 μM; SU86.86, 2.31±0.23 μM; Panc-1, 0.66 ±0.02 μM; HPDE, 2.39±0.29 μM[2].
SRT 1460 (5 μM; 16 hours) increases expression of the autophagy marker LC3-II[2].
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