BT-13
CAS No. : 924537-98-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $320 | In-stock |
| 100mg | $500 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124401 |
| M.Wt: | 517.54 |
| Formula: | C23H27F4N3O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat[1]. IC50 & Target:GDNF receptor RET[1]. In Vitro: BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET[1]. In Vivo: BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy[1].
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