HBX 41108
CAS No. : 924296-39-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $720 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101666 |
| M.Wt: | 266.64 |
| Formula: | C13H3ClN4O |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic;warming;heat to 60°C) |
HBX 41108 is an inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. BX 41108 can be used in cancer and diabetes research[1][2][3][4].
In Vitro:HBX 41108 (0-3 μM, 24 h) inhibits the proliferation of tumor cells HCT-116, induces P53 dependent apoptosis and does not affect the activity of normal hepatocytes [1].
HBX 41108 (5 μM, 24 h) can inhibit cell cycle arrest and cell senescence induced by USP7 in HUVECs[3].
HBX 41108 (5-25 μM, 48 h) can enhances the hTPH2 promoter activity in RN46A cells[4].
In Vivo:HBX 41108 (100 mg/kg/day for 14 days, i.p.) can promote wound healing and reduce blood sugar levels in diabetic rats [3].
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