DUB-IN-3
CAS No. : 924296-17-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $420 | In-stock |
| 10mg | $600 | In-stock |
| 50mg | $1400 | In-stock |
| 100mg | $1960 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-50737 |
| M.Wt: | 287.28 |
| Formula: | C16H9N5O |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
DUB-IN-3 (compound 22c) is a potent and selective inhibitor of the deubiquitinating enzyme USP8 with an IC50 value of 0.56 μM. DUB-IN-3 is promising for research of cancer, neurodegenerative diseases, inflammation, viral infection and cardiovascular disease[1].
IC50 & Target:IC50: 0.56 μM (USP8)[1]
In Vitro: DUB-IN-3 (10 nM-100 μM) affects the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50 values of 0.5-1.5 μM range[1].
Inhibitory effect of DUB-IN-3 on USP7 and USP8 deubiquitinating activity (IC50: μM)[1]
| Compd | USP7 | USP8 |
| DUB-IN-3 | >100 | 0.56 |