Navitoclax (Standard)
CAS No. : 923564-51-6
(Synonyms: ABT-263 (Standard))
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| Cat. No. : | HY-10087R |
| M.Wt: | 974.61 |
| Formula: | C47H55ClF3N5O6S3 |
| Purity: | >98 % |
| Solubility: |
Navitoclax (Standard) (ABT-263 (Standard)) is the analytical standard of Navitoclax (HY-10087). This product is intended for research and analytical applications. Navitoclax (ABT-263 ) is an orally active BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w, with a Ki value of <1 nM for each target. Navitoclax triggers endogenous Apoptosis and downregulates the expression of Survivin and TGFβ2. Navitoclax alleviates fibrosis and induces thrombocytopenia. Navitoclax exhibits anticancer activity against a variety of tumors and enhances the efficacy of chemotherapy and radiotherapy. Navitoclax can be used in the research of acute lymphoblastic leukemia, ovarian cancer, and fibrotic diseases[1][2][3][4][5][6].
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