HS56
CAS No. : 922050-57-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $189 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-123983 |
| M.Wt: | 317.75 |
| Formula: | C13H8ClN5OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension[1]. In Vitro:HS56 (50 μM; 16 h) delays force onset, decreases contractile force, and reduces LC20 phosphorylation in excised rat caudal arterial VSM tissues[1]. In Vivo:HS56 (10 and 20 mg/kg; i.v.; single injection) decreases blood pressure (BP) in spontaneously hypertensive mice[1].
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