Fosphenytoin (disodium)
CAS No. : 92134-98-0
| Size | Price | Stock |
|---|---|---|
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| 10mg | $40 | In-stock |
| 25mg | $72 | In-stock |
| 50mg | $111 | In-stock |
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| Cat. No. : | HY-B1657A |
| M.Wt: | 406.24 |
| Formula: | C16H13N2Na2O6P |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL |
Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials. In Vivo: Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed[1]. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg)[2].
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