Cilazapril (monohydrate)
CAS No. : 92077-78-6
(Synonyms: Ro 31-2848 monohydrate)
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $320 | In-stock |
| 25mg | $640 | In-stock |
| 50mg | $1025 | In-stock |
| 100mg | $1640 | In-stock |
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| Cat. No. : | HY-A0043A |
| M.Wt: | 435.51 |
| Formula: | C22H33N3O6 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;0.1 M NaOH : 14.29 mg/mL (ultrasonic;warming;adjust pH to 10 with NaOH;heat to 60°C) |
Cilazapril monohydrate is an orally active prodrug of the angiotensin-converting enzyme (ACE) inhibitor Cilazaprilat (HY-A0113). Cilazapril monohydrate reduces plasma ACE activity. Cilazapril monohydrate can be used in the research of hypertension (including essential and renal hypertension) and congestive heart failure[1][2][3][4][5].
In Vivo:Cilazapril (0.1 mg/kg; p.o.) monohydrate evokes the same maximum degree of plasma ACE inhibition (-76%) in rats as 0.25 mg/kg Enalapril (HY-B0331)[1].
Cilazapril (0.1-0.3 mg/kg orally) monohydrate dose-dependently reduces plasma ACE activity and the pressor response to angiotensin in cats[1].
Cilazapril (10 mg/kg orally twice daily for 3.5 days) monohydrate gradually reduces blood pressure in dogs with volume-depleted renal hypertension.
Cilazapril (10 mg/kg; p.o.; 2 weeks) monohydrate decreases blood pressure, reduces heart weight to body weight ratio, and improves postischemic myocardial function in hyperthyroid rats[3].
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