5-HEPE
CAS No. : 92008-51-0
| Size | Price | Stock |
|---|---|---|
| 314.02 μM * 1 mL in Ethanol | $1104 | Get quote |
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| Cat. No. : | HY-113513 |
| M.Wt: | 318.45 |
| Formula: | C20H30O3 |
| Purity: | >98 % |
| Solubility: |
5-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119). 5(S)-HEPE increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.
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