Thianthrene
CAS No. : 92-85-3
| Size | Price | Stock |
|---|---|---|
| 25g | $12 | In-stock |
| 100g | $32 | In-stock |
| 500g | $148 | In-stock |
| 1000g | $252 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-W014120 |
| M.Wt: | 216.33 |
| Formula: | C12H8S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 11.11 mg/mL (ultrasonic;warming;heat to 60°C) |
Thianthrene is a potent and orally active inhibitor of Leishmania donovani pteridine reductase 1 (PTR1). Thianthrene is a sulfur-containing tricyclic molecule distributed widely within the macro-structure of hydrocarbon fossil fuels. Thianthrene inhibits the intracellular amastigotes of Leishmania donovani (IC50 = 23 μM). Thianthrene has a moderate anthelmintic activity. Thianthrene appears to inhibit RNA function and subsequent protein production. Thianthrene can stimulate liver regeneration in vivo[1][2].
In Vitro:Thianthrene (2-6 μg/mL) reduces the infection rate measured by MFI of macrophages[2].
Thianthrene inhibits the intracellular amastigotes of L. donovani (IC50 = 23 μM)[2].
In Vivo:Thianthrene (100-900 mg/kg, p.o., single dose) appears to have no toxicity in Wistar rats[1].
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