Phenothiazine
CAS No. : 92-84-2
(Synonyms: Thiodiphenylamine)
| Size | Price | Stock |
|---|---|---|
| 100g | $20 | In-stock |
| 250g | $25 | In-stock |
| 500g | $30 | In-stock |
| 1000g | $53 | In-stock |
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| Cat. No. : | HY-Y0055 |
| M.Wt: | 199.28 |
| Formula: | C12H9NS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].
In Vitro:Phenothiazine inhibits cell death caused by oxidative stress in cells HT22 (causes by glutamate, EC50=0.02 μM), SK-N-MC (causes by H2O2, EC50=0.02 μM)and SH-SY5Y (causes by MPP+, EC50=0.02 μM). Phenothiazine inhibits lipid peroxidation in Ascorbate (HY-B0166)-damaged pig brain membranes, exhibits antioxidant efficacy[3].
In Vivo:Phenothiazine causes acute hemolytic anemia, exhibits neurotoxicity and phototoxicity in pigs and horses[2].
Phenothiazine protects dopaminergic neurons from the toxic effects of MPP+ and Rotenone (HY-B1756) in C. elegans models[3].
Phenothiazine (5-30 mg/kg, sc, single dose) reduces brain lesions, and exhibits neuroprotective efficacy in traumatic brain injury (TBI) mouse models[4].
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