Dehydrothio-p-toluidine

Dehydrothio-p-toluidine (DHPT) is a chemical intermediate used in dyestuff production. Dehydrothio-p-toluidine shows inhalation toxicity in acute and subchronic conditions^[1]. In Vivo:Dehydrothio-p-toluidine (4 h) induces salivation, pawing and chewing motions, lachrymation, sporadic fasciculations, rapid respiration and slight weight loss of mice under an average of 0.64 mg DHPT/L condition^[1].
Dehydrothio-p-toluidine (4 h) induces sporadic nasal discharge and lethargy of mice under an average of 2.41 mg DHPT/L condition^[1].
Dehydrothio-p-toluidine (6 h/day on 5 days followed by two rest days and then by five additional days of exposures; 0.6 mg DHPT/L) decreases the erythrocyte count, haemoglobin level and relative number of lymphocytes than in the controls, excrets a larger volume of less-concentrated urine, produces liver changes characterized by hepatocyte hyper trophy and proliferation of bile-duct epithelial cells and induxes thymic necrosis and depletion of lymphocytes after the tenth exposure^[1].