Trichlormethiazide (sodium)
CAS No. : 91996-54-2
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| Cat. No. : | HY-B0235A |
| M.Wt: | 403.65 |
| Formula: | C8H8Cl3N3NaO4S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model[1][2].
In Vivo: Trichlormethiazide (1 mg/kg; p.o.; once) sodium increases urinary volume, sodium and potassium excretion in rats[1].
Trichlormethiazide (10 mg/kg, i.v.; daily for 5 days) sodium significantly reduces mean arterial pressure (MAP) within 24 h in high salt intake (HS) rats receiving angiotensin II, but does not affect MAP in any other group[2].
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