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p-Cresyl sulfate (potassium)


CAS No. : 91978-69-7

(Synonyms: p-Tolyl sulfate (potassium))

91978-69-7
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Cat. No. : HY-111431A
M.Wt: 226.29
Formula: C7H7KO4S
Purity: >98 %
Solubility: H2O : ≥ 100 mg/mL;DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 91978-69-7 :

p-Cresyl sulfate (p-Tolyl sulfate) potassium is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate potassium shows antiproliferation activity. p-Cresyl sulfate potassium increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate potassium induces epithelial-mesenchymal transition (EMT). p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways[1][2][3]. In Vitro:p-Cresyl sulfate potassium (0-500 μM; 0-48 h) shows antiproliferation activity in a dose- and time-dependent manner[1].
p-Cresyl sulfate potassium (100, 200 μM; 1, 3, 5 days) increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α[1].
p-Cresyl sulfate potassium (40 µg/mL) inhibits lipogenesis and increases lipolysis in adipocytes in 3T3-L1 cells[2].
p-Cresyl sulfate potassium (0.125 mM, 24 h) induces osteoblast dysfunction through activating JNK and p38 MAPK pathways[3].
p-Cresyl sulfate potassium (0-0.5 mM; 60 min) induces ROS production in primary osteoblastic cells[3]. In Vivo:p-Cresyl sulfate potassium (10 mg/kg; IP; twice daily for 4 weeks) exhibits hyperglycemia and hypercholesterolemia[2].

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