UCL 2077
CAS No. : 918311-87-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $105 | In-stock |
| 10mg | $157 | In-stock |
| 25mg | $284 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $595 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-108592 |
| M.Wt: | 350.46 |
| Formula: | C25H22N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
UCL 2077 is a potassium channel and slow afterhyperpolarization (sAHP) inhibitor. UCL 2077 selectively blocks sAHP channels without affecting L-type Ca2+ currents. UCL 2077 blocks KCNQ1- and KCNQ2-containing K+ channels, decreases erg current amplitude, increases erg deactivation rate. UCL 2077 can be used for the research of hippocampus-dependent memory retrieval deficit and cardiac arrhythmias[1][2][3].
In Vitro:UCL 2077 potently and selectively blocks the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurons with an IC50 of 0.5 μM[1].
UCL 2077 (0.1-100 µM) potently inhibits erg-mediated potassium current in pituitary GH3 cells with an IC50 of 4.7 µM and Kd of 5.1 µM[2].
UCL 2077 (30 µM) significantly reduces both activation (za) and deactivation (z(deact)) gating charges of IK(erg) in pituitary GH3 cells[2].
UCL 2077 (3-30 µM) concentration-dependently reduces the voltage hysteresis of IK(erg) in pituitary GH3 cells, with 10 µM decreasing the hysteresis area by approximately 50%[2].
UCL 2077 (1-100 µM) inhibits delayed-rectifier potassium current (Ik(DR)) in pituitary GH3 cells with an IC50 of 13.4 µM[2].
UCL 2077 (3-30 µM) concentration-dependently reduces the open probability of IKca channels in pituitary GH3 cells without altering single-channel amplitude, and this suppression is reversed by 9-Phenanthrol (HY-108457)[2].
UCL 2077 (3-10 µM) concentration-dependently increases spontaneous action current frequency in pituitary GH3 cells, and this effect is abolished by KCNH2 siRNA knockdown, indicating dependence on erg potassium channels[2].
In Vivo:UCL 2077 (0.5-2 μg/dorsal hippocampus; central infusion into dorsal hippocampus; single dose) rescues contextual fear memory retrieval in norepinephrine/epinephrine-deficient Dbh-/- mice[1].
UCL 2077 (2 μg/dorsal hippocampus; central infusion into dorsal hippocampus; single dose) fully rescues contextual fear memory retrieval in β1-adrenergic receptor-deficient β1 KO mice without altering non-specific freezing behavior[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- UCL 2077
- Cat. No.:
- HY-108592
- Quantity:
Your information is safe with us.