JT010
CAS No. : 917562-33-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $510 | In-stock |
| 100mg | $820 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-111132 |
| M.Wt: | 354.85 |
| Formula: | C16H19ClN2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
JT010 is a covalent and site-selective TRPA1 agonist. JT010 can be used in myocardial infarction research[1][2][3][4][5][6].
IC50 & Target:EC50: 0.65 nM (TRPA1)[1]
In Vitro: JT010 (1-40 μM, 10 min before activation of cells) shows a concentration-dependent inhibitory effect on T-cell receptor (TcR)-induced Ca2+ signals in CD4+ T lymphocytes[2].
JT010 (0.3-100 nM) activates TRPA1 in human cells HEK-hTRPA1[3].
JT010 (50 nM) induces activation of TRPA1 ion currents in human lung tissue but also did not modify fibrosis relevant gene expression in the presence of TGFβ1[4].
JT010 (100 nM) shows a mean ATP concentration of 0.52 μM in DRGN cells[5].
In Vivo: JT010 (0.4 mg/kg, i.v., 60 or 5 min prior to left coronary artery occlusion and 5 min prior to onset of the reperfusion) and A-967079 (HY-108463) have small opposing effects on myocardial infarct size in male rats[6].
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