HA-1004
CAS No. : 91742-10-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $260 | In-stock |
| 5mg | $640 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-123468 |
| M.Wt: | 293.34 |
| Formula: | C12H15N5O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models[1][2][3]. IC50 & Target:cyclic GMP-dependent protein kinase, cyclic AMP-dependent protein[2] In Vivo:HA-1004 (40 nmol/day; infused by minipumps and delivered at 1 μL/h), it acts simultaneously with morphine to antagonize the phosphorylation of ERK1/2 and TH and inhibit the increase of NA conversion during morphine withdrawal in rats[1].
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