(2-Chloropyridin-4-yl)methanamine hydrochloride
CAS No. : 916210-98-5
| Size | Price | Stock |
|---|---|---|
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| 250mg | $44 | In-stock |
| 1g | $69 | In-stock |
| 5g | $218 | In-stock |
| 10g | $270 | In-stock |
| 25g | $675 | In-stock |
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| Cat. No. : | HY-101771A |
| M.Wt: | 179.05 |
| Formula: | C6H8Cl2N2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 33 mg/mL;H2O : ≥ 50 mg/mL |
(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM. IC50 & Target: IC50: 126 nM (LOXL2)[1] In Vitro: (2-Chloropyridin-4-yl)methanamine hydrochloride is shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B and SSAO). In the human whole blood LOXL2 assay, (2-Chloropyridin-4-yl)methanamine hydrochloride has an IC50 of 1.45 µM compared to 126 nM in the absence of blood proteins. (2-Chloropyridin-4-yl)methanamine hydrochloride shows a 31-fold selectivity for LOXL2+BSA (IC50=190 nM) over LOX+BSA (IC50=5.91 µM). Against a panel of non-LTQ-containing AO enzymes (MAO-A, MAO-B and SSAO), LOXL2-IN-1 is found to be inactive at 30 µM. (2-Chloropyridin-4-yl)methanamine hydrochloride is profiled for the inhibition of three different CYP enzymes (CYPs 3A4, 2C9 and 2D6) and in each case the IC50 is more than 30 µM[1].
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