Naldemedine
CAS No. : 916072-89-4
(Synonyms: S-297995)
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| Cat. No. : | HY-19627 |
| M.Wt: | 570.64 |
| Formula: | C32H34N4O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Naldemedine (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA)[1]. Naldemedine shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors[2]. Naldemedine can be used in opioid-induced constipation (OIC) research[2]. Naldemedine is predicted to bind to 3CLpro encoded by SARS-CoV2 genome[3]. In Vivo: Naldemedine (oral gavage; 0.03-10 mg/kg; once) represses the opioid-induced inhibition of small intestinal transit in rats by subcutaneous morphine and oxycodone[2].
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