Cot inhibitor-2
CAS No. : 915363-56-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $195 | In-stock |
| 10mg | $310 | In-stock |
| 25mg | $650 | In-stock |
| 50mg | $1040 | In-stock |
| 100mg | $1665 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-32018 |
| M.Wt: | 539.43 |
| Formula: | C26H25Cl2FN8 |
| Purity: | >98 % |
| Solubility: | DMSO : 40 mg/mL (ultrasonic) |
Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM[1]. IC50 & Target: COT/Tpl2[1] In Vivo: Cot inhibitor-2 (compound 34) is orally administered in rats with 100 mg/kg dosing and showed a Cmax of 517 ng/mL (0.89 μM) and AUC of 4841 ng•h/mL. Cot inhibitor-2 is tested in the LPS-induced TNF-α production model in female Sprague-Dawley rats. With a 25 mg/kg po dose, Cot inhibitor-2 inhibits LPS-induced TNF-α production by 83%[1].
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Inquiry Information- Product Name:
- Cot inhibitor-2
- Cat. No.:
- HY-32018
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