Indotecan
CAS No. : 915303-09-2
(Synonyms: LMP-400; NSC-724998)
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $256 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $720 | In-stock |
| 100mg | $1150 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-18351 |
| M.Wt: | 478.49 |
| Formula: | C26H26N2O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C) |
Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2].
IC50 & Target:Topoisomerase I[1]
In Vitro:Indotecan (48 h) inhibits the proliferation of L. infantum promastigotes, ex vivo-infected splenocytes, and uninfected splenocytes, with IC50s of 0.10 μM, 0.10 μM, and 57.16 μM, respectively[2].
Indotecan (1.1-90 μM; 30 min) induces TopI-DNA complexes and inhibits DNA synthesis in L. infantum cultures[2].
In Vivo:Indotecan (2.5 mg/kg; i.p. every 2 d for 15 d) depletes the parasitic burden in the spleen and liver of visceral leishmaniasis mice[2].
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