Elotuzumab
CAS No. : 915296-00-3
(Synonyms: HuLuc 63; PDL 063; BMS 901608)
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $850 | In-stock |
| 10mg | $1300 | In-stock |
| 25mg | $2150 | In-stock |
| 50mg | $3200 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-P9965 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma[1][2]. In Vitro:Elotuzumab (0.1-10 μg/mL; 4-20 h) upregulates the expression of CD107a, CD69 and CD54 on NK cells, and promotes the secretion of IFN-γ and TNF-α in a co-culture system of human PBMC and OPM-2 cells[2]. In Vivo:Elotuzumab (10 mg/kg; intraperitoneal injection; 3 times; once every 3-4 days) exhibits antitumor activity in a mouse tumor model expressing hSLAMF7, and the effect is better when used in combination with anti-PD-1 antibody[2].
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