Timolol (hemihydrate)
CAS No. : 91524-16-2
(Synonyms: (S)-L-714,465 (hemihydrate); MK 950 (hemihydrate))
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| Cat. No. : | HY-17494A |
| M.Wt: | 325.43 |
| Formula: | C13H24N4O3S.1/2H2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Timolol (hemihydrate) is a β-blocker available for both topical and systemic administration. Timolol (hemihydrate) is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension and Timolol (hemihydrate) also has cardioprotective effect[1][2]. In Vitro: Timolol (hemihydrate) can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol (hemihydrate) can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3]. In Vivo: Timolol (hemihydrate) (5 mg/kg daily for 12-week) has a cardioprotective effect via inhibition of ERS response in diabetic rats[3].
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