MF498
CAS No. : 915191-42-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $380 | In-stock |
| 50mg | $610 | In-stock |
| 100mg | $980 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-10794 |
| M.Wt: | 603.69 |
| Formula: | C32H33N3O7S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL |
MF498 is a selective and orally active E prostanoid Receptor 4 (EP4) antagonist with a Ki value of 0.7 nM. MF498 can be used in the research of inflammation, such as rheumatoid and osteoarthritis[1][2].
In Vitro:MF498 (0.01 nM-10 μM, 30 min) inhibits PGE2-stimulated cAMP accumulation with IC50 values of 1.7 and 17 nM in the absence and presence of 10% serum, respectively[1].
MF498 (0.01 and 0.1 μM, 30 min) inhibits FBS and PDGF-BB-induced VSMC proliferation in rat VSMCs[2].
MF498 (0.1 μM, 30 min) reduced PDGF-induced cyclin D1 and PCNA expression in rat VSMCs[2].
MF498 (0.1 μM, 30 min) inhibits the PDGF-BB-induced migration[2].
In Vivo:MF498 (0-20 mg/kg, p.o.) inhibits paw swelling in rats with adjuvant-induced arthritis (AIA)[1].
MF498 (0-30 mg/kg, p.o.) attenuates the EP4 agonist-(L-902688)-induced hyperalgesia in guinea pigs[1].
MF498 (20 mg/kg, p.o.) shows 100% bioavailability, resulting in plasma concentration of 1.2 μM at 6 h[1].
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