Shield-1
CAS No. : 914805-33-7
(Synonyms: Shld1)
| Size | Price | Stock |
|---|---|---|
| 1mg | $200 | In-stock |
| 5mg | $450 | In-stock |
| 10mg | $730 | In-stock |
| 25mg | $1200 | In-stock |
| 50mg | $1600 | In-stock |
| 100mg | $2150 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112210 |
| M.Wt: | 748.90 |
| Formula: | C42H56N2O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 67.5 mg/mL (ultrasonic;warming;heat to 60°C) |
Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD)[1][2][3]. In Vitro: Shield-1 (0.1 nM-1 μM) responses characterization of destabilizing domains[1]. Shield-1 (1 μM; 24 h) treatment shows excellent expression on both TRPV5 and YFP when fused the mtFKBP destabilizing domain to either TRPV5 or YFP, and leads to mtFKBP-TRPV5 forming a functional ion channel[2].
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