CAS No. : 914613-86-8
(Synonyms: (S)-Omeprazole (hemistrontium); (-)-Omeprazole (hemistrontium))
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| Cat. No. : | HY-17021C |
| M.Wt: | 388.22 |
| Formula: | C17H18N3O3S.1/2Sr |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Esomeprazole ((S)-Omeprazole) hemistrontium is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole hemistrontium has the potential for symptomatic gastroesophageal reflux disease research[1][2][3]. In Vitro: Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) hemistrontium treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification[1]. In Vivo: Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) hemistrontium treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis[2].
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