Fostamatinib (disodium hexahydrate)
CAS No. : 914295-16-2
(Synonyms: R788 (disodium hexahydrate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $96 | In-stock |
| 10mg | $144 | In-stock |
| 25mg | $315 | In-stock |
| 50mg | $432 | In-stock |
| 100mg | $708 | In-stock |
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| Cat. No. : | HY-13038B |
| M.Wt: | 732.51 |
| Formula: | C23H36FN6Na2O15P |
| Purity: | >98 % |
| Solubility: | H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 25 mg/mL (ultrasonic) |
Fostamatinib (R788) disodium hexahydrate is the oral prodrug of the active compound R406[1]. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM[2]. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[3]. IC50 & Target: Syk, FLT3[2] In Vivo: Fostamatinib (R788) is highly bioavailable, and rapidly absorbed in Louvain rats. R406 following a single oral dose of R788 10 mg/kg or 20 mg/kg: AUC0-16 hrs= 10618 ng*h/mL and 30650 ng*h/mL respectively; Cmax=2600 ng/mL and 6500 ng/mL respectively (observed at 1 hour); t1/2=4.2 hours. The prodrug was not detected in plasma suggesting R788 is completely converted to R406[1].
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