PS372424
CAS No. : 914291-61-5
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| Cat. No. : | HY-111149 |
| M.Wt: | 588.74 |
| Formula: | C33H44N6O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation[1][2].
IC50 & Target: Human CXCR3[2]
In Vitro: PS372424 (100?ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5?min of stimulation[1].
PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells[2].
PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC50 of 42±21 nM[3].
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