Lu AA47070
CAS No. : 913842-25-8
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| Cat. No. : | HY-14408 |
| M.Wt: | 463.39 |
| Formula: | C17H20F2N3O6PS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade[1][2].
In Vivo:Lu AA47070 (3.75, 7.5, 15, 30 mg/kg; i.p.) reverseS the tremulous jaw movements, catalepsy, and locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (1.0 mg/kg IP)[2].
Pharmacokinetic Parameters of Lu AA47070 in Sprague-Dawley rats[1].
| Compd | dose （mg/kg） | AUC(ng*h/L) | Tmax (h) | Cmax (ng/mL) | F (%) |
| 32 | 1.5 | 2.9±0.7 | 0.5±0.1 | 869±68 | 55±13 |
| 32 | 15 | 35±3.0 | 0.4±0.2 | 6413±281 | 66±6 |
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