Ropinirole (hydrochloride)
CAS No. : 91374-20-8
(Synonyms: SKF 101468 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 50mg | $66 | In-stock |
| 100mg | $99 | In-stock |
| 200mg | $132 | In-stock |
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| Cat. No. : | HY-B0623A |
| M.Wt: | 296.84 |
| Formula: | C16H25ClN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[1][2]. IC50 & Target:Ki: D3 and 29 nM (D2)[1] In Vitro: Ropinirole hydrochloride has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors[1][2]. In Vivo: Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory[2].
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