AR-9281
CAS No. : 913548-29-5
(Synonyms: APAU)
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $480 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-111151 |
| M.Wt: | 319.44 |
| Formula: | C18H29N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes[1][2]. IC50 & Target:IC50: 13.8 nM (HsEH); 1.7 nM (MsEH)[1] In Vitro:AR-9281 (APAU) has inhibitory activity for human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively[1]. In Vivo:AR-9281 (APAU) (oral, 150-200 mg/dL, for 6 weeks) enhances the therapeutic effects of EETs, slows progression of hyperglycemia, protects the myocyte structure, and reduces Ca2+ dysregulation and SERCA remodeling in hyperglycemic rats[2].
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