BMS-582949 (hydrochloride)
CAS No. : 912806-16-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $78 | In-stock |
| 10mg | $123 | In-stock |
| 25mg | $208 | In-stock |
| 50mg | $333 | In-stock |
| 100mg | $495 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-14305A |
| M.Wt: | 442.94 |
| Formula: | C22H27ClN6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC50 of 13 nM. BMS-582949 hydrochloride displays a significantly improved pharmacokinetic profile and is effective in inflammatory disease[1].
In Vitro: BMS-582949 displays a p38α IC50 of 13 nM and a cellular TNFα IC50 of 50 nM[1].
BMS-582949 is a weak inhibitor of CYP3A4 BMS-582949 displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases that include serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms[1].
In Vivo: BMS-582949 (5-100 mg/kg, orally) is effective in both the acute murine model of inflammation and rat adjuvant arthritis model despite its slightly reduced potency[1].
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