ML115
CAS No. : 912798-42-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $290 | In-stock |
| 10mg | $460 | In-stock |
| 25mg | $800 | In-stock |
| 50mg | $1100 | In-stock |
| 100mg | $1500 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-111152 |
| M.Wt: | 322.74 |
| Formula: | C15H15ClN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C) |
ML115, a molecular probe of the signal transducer, is a selective STAT3 agonist, with an EC50 of 2 nM. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene. ML115 is inactive against the related STAT1, STAT5 and NF-κB anti-targets. ML115 counteracts the effects of Ginsenoside Rc (HY-N0042) on cell viability and inflammatory responses in LPS (HY-D1056)-stimulated H9c2 and RAW264.7 cells, while altering oxidative stress markers. ML115 can be used for the study of breast and prostate cancers[1][2].
In Vitro:ML115 (10 µM, 48 h) reverses the Ginsenoside Rc (HY-N0042)-induced improvement in viability of LPS (HY-D1056)-stimulated H9c2 cells, increases MDA levels, and decreases SOD and GSH-Px activities[1].
ML115 (10 µM, 6 h) reverses the Ginsenoside Rc-induced downregulation of IL-1β, TNF-α, iNOS and COX2, and upregulation of Arg1 and Ym1 in LPS-treated RAW264.7 cells, and also reverses the Ginsenoside Rc-induced reduction in IL-1β and TNF-α production[1].
ML115 exhibits no cytotoxicity in HT-1080 and NIH-3T3 cells[2].
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