S-Diclofenac
CAS No. : 912758-00-0
(Synonyms: ACS 15; ATB-337)
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $620 | In-stock |
| 100mg | $930 | In-stock |
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| Cat. No. : | HY-15035 |
| M.Wt: | 504.47 |
| Formula: | C23H15Cl2NO2S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
S-Diclofenac (ACS 15) is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac activates the p53 signaling pathway, and inhibits the activation of JNK. S-Diclofenac exhibits antioxidant and anti-inflammatory activities[1][2][3][4].
In Vitro:S-Diclofenac (0-100 μM, 48 h) induces the expression of p53 protein, thereby activating downstream proteins such as p21, p53AIP1 and Bax. S-Diclofenac arrests the cell cycle at sub-G1 phase, and induces apoptosis in rat aortic vascular smooth muscle cells[4].
In Vivo:S-Diclofenac (6-24 mg/kg, ip, single dose) releases hydrogen sulfide (H2S) and inhibits cyclooxygenase-mediated inflammatory responses, ameliorates Carrageenan (HY-125474)-induced hindpaw edema in rats models[2].
S-Diclofenac (12.5-25 mg/kg, ip, one daily for 14 days) reverses the remodeling of cardiac gap junctions, alleviates oxidative stress and inflammatory response, thereby reducing Doxorubicin (HY-15142)-induced myocardial injury and cardiac dysfunction in mouse models[3].
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