XEN907
CAS No. : 912656-34-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-19958 |
| M.Wt: | 351.40 |
| Formula: | C21H21NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain[1][2].
IC50 & Target: IC50: 3 nM (NaV1.7)[1]
In Vitro: XEN907 is not cytotoxic in HepG2 cells (% viable after 16 h: >99%)[1].
XEN907 shows moderate hepatocyte stability (% remaining after 2 h: rat 21%; human 34%; dog 46%) across species[1].
In Vivo: XEN907 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (13 %), Cmax (35 ng/mL), and AUClast (143 h•ng/mL) in rats[1].
XEN907 (3 mg/kg; i.v.) exhibits terminal elimination half-life (2.6 h), high plasma clearance (9.4 L/h/kg), and large volumes of distribution (35.0 L/kg) in rats[1].
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