Selurampanel
CAS No. : 912574-69-7
(Synonyms: BGG 492)
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| Cat. No. : | HY-105860 |
| M.Wt: | 377.42 |
| Formula: | C16H19N5O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC50 of 190 nM. Selurampanel has reasonable blood-brain barrier penetration. Selurampanel can be used for epilepsy research[1][2].
In Vivo: Selurampanel (Compound 1S) potently and dose-dependently antagonizes maximal electroshock seizure (MES)-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment[1].
In a study with a 3 mg/kg i.v. dose, a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min kg[1].
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