SAG
CAS No. : 912545-86-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $60 | In-stock |
| 5mg | $120 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $675 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12848 |
| M.Wt: | 490.06 |
| Formula: | C28H28ClN3OS |
| Purity: | >98 % |
| Solubility: | H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : ≥ 38 mg/mL |
SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3].
IC50 & Target:EC50: 3 nM (Smo)[1]
In Vitro: SAG (0.1 nM-100 μM; 30 h) induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM and then inhibits expression at higher concentrations[1].
SAG (1-1000 nM; 1 h) competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells, yielding an apparent dissociation constant (Kd) of 59 nM for the SAG/Smo complex[1].
SAG (100 nM) inhibits the inhibitory effect of ShhN-induced pathway activation by Robotnikinin[2].
SAG (250 nM; 48 h) significantly increases SMO mRNA and protein expression in MDAMB231 cells[3].
SAG (250 nM; 24 and 48 h) increases CAXII mRNA expression in MDAMB231 cells at 24h in normoxic and hypoxic conditions in MDAMB231 cells[3].
SAG (250 nM; 24 h) increases MDAMB231 cells migration[3].
In Vivo: SAG (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight-week timepoint in CD-1 mice[4].
SAG (15-20 mg/kg; i.p.) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice[5].
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