YHO-13177
CAS No. : 912287-56-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $410 | In-stock |
| 100mg | $656 | In-stock |
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| Cat. No. : | HY-12757 |
| M.Wt: | 370.47 |
| Formula: | C20H22N2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
YHO-13177, a acrylonitrile derivative, is an orally active, potent and specific inhibitor of breast cancer resistance protein (BCRP) and ABCG2 with an IC50 value of 10 nM. YHO-13177 potentiates the cytotoxicity of SN-38 in HCT116 and A549 cells that express BCRP. YHO-13177 combined with Irinotecan (HY-16562) significantly suppresses the tumor growth in an HCT116/BCRP xenograft model[1][2][3].
In Vitro:YHO-13177 (0.01 to 1 μM, 96 h) reverses BCRP-mediated drug resistance and sensitivity in a concentration-dependent manner in various BCRP-transduced cancer cells[1].
YHO-13177 (0.01 to 1 μM, 96 h) decreases the expression of BCRP protein in HCT116 and HCT116/BCRP cells, or A549 and A549/SN4 cells[1].
YHO-13177 (0-0.1 μM, 96 h) reduces the side population cell ratio in HeLa cells in a concentration-dependent manner[2].
In Vivo:YHO-13177 (19.7μM, i.v., or 27.3μM, p.o., a single dose for 25 days) is converted by YHO-13351, increases the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppresses the tumor growth in an HCT116/BCRP xenograft mouse model[1].
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