Spantide I
CAS No. : 91224-37-2
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| 10mg | $245 | In-stock |
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| Cat. No. : | HY-P1194 |
| M.Wt: | 1497.79 |
| Formula: | C75H108N20O13 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Spantide I, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation[1][2][3].
In Vivo: Spantide I (50 and 100 nM perfused through the cerebral ventricles) causes a complete respiratory arrest in all of the examined animals[2].
Spantide I (36 μg/mouse, ip daily) significantly decreases the number of perforated corneas, bacterial counts, and PMNs. Spantide I also downregulates the mRNA levels for type I cytokines (e.g., IFN-γ) as well as MIP-2, IL-6, TNF-α, and IL-1β[3].
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