Gemigliptin
CAS No. : 911637-19-9
(Synonyms: LC15-0444)
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|---|---|---|
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| 10mg | $110 | In-stock |
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| 100mg | $520 | Get quote |
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| Cat. No. : | HY-14892 |
| M.Wt: | 489.36 |
| Formula: | C18H19F8N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Gemigliptin (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin exhibits potent anti-glycation properties. Gemigliptin can be used for the research of advanced glycation end products (AGE)-related diabetic complications[1][2].
IC50 & Target:IC50: 10.3 nM (human recombinant DPP-4)[2]
In Vitro: Gemigliptin dose-dependently inhibits the formation of AGE-BSA with IC50 of 11.69 mM[1].
Gemigliptin dose-dependently suppressed the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM[1].
Gemigliptin is a competitive inhibitor with a Ki of 7.25 nM[2].
In Vivo: Gemigliptin (100 mg/kg; i.g.; daily; for 12 weeks) inhibits AGEs formation and AGE cross-links in vivo[1].
Gemigliptin dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys[2].
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