Belumosudil
CAS No. : 911417-87-3
(Synonyms: KD025; SLx-2119)
| Size | Price | Stock |
|---|---|---|
| 5mg | $84 | In-stock |
| 10mg | $114 | In-stock |
| 25mg | $202 | In-stock |
| 50mg | $310 | In-stock |
| 100mg | $475 | In-stock |
| 500mg | $1130 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-15307 |
| M.Wt: | 452.51 |
| Formula: | C26H24N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : ≥ mg/mL |
Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties[1]. IC50 & Target:IC50: 105 nM (ROCK2)[1] In Vitro:Belumosudil (SLx-2119; 40 μM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. The microarray hybridized with aRNA from HMVEC treated with Belumosudil, shows a 5-times higher background than the other arrays[1]. In Vivo:Belumosudil (KD-025; 100, 200 or 300?mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. Belumosudil is at least as efficacious in aged, diabetic or female mice, as in normal adult males[2].
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