PPI-4955
CAS No. : 911412-31-2
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| Cat. No. : | HY-16621 |
| M.Wt: | 467.48 |
| Formula: | C26H24F3N3O2 |
| Purity: | >98 % |
| Solubility: |
PPI-4955 is a subtype 1 (S1P₁) agonist of sphingosine-1-phosphate receptor with an EC50 of 1.62 nM. PPI-4955-P (the active phosphorylated form) exhibits excellent receptor selectivity and affinity, and the IC50 values for hS1P₁, hS1P₃, hS1P₄, and hS1P₅ are 0.23, 2000, 6.5, and 184 nM respectively. PPI-4955 has significantly improved in vivo phosphorylation efficiency, which can reduce lymphocytes and improve cardiovascular risk. PPI-4955 can be used in immunomodulation research[1].
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